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Sequential injection spectrophotometric determination of analgine in pharmaceutical formulations using 18-molybdo-2-phosphate heteropoly anion as chromogenic reagent

Mohammed Khair E. A. Al-Shwaiyat, Andriy B. Vishnikin, Ludmila P. Tsiganok, Ekaterina V. Kabashnaya, Svetlana A. Khmelovskaya, Vasil Andruch, Yaroslav R. Bazel, Hana Sklenářová, Petr Solich


Simple, sensitive and selective sequential injection analysis (SIA) method for the analgine determination has been developed on the basis of fast reaction between analgine and 18-molybdo-2-phosphate heteropoly anion (18-MPA). Under found optimal conditions (0.01 M HCl, C(18-MPA) = 2 mmol/L) linear calibration curve was obtained over the range from 0.5 to 80 mg/L of analgine, and detection limit (S/N = 3) was 0.2 mg/L. The proposed SIA method has high sample throughput of 45 h-1 and small reagent consumption (0.08 mL). The procedure was successfully applied to the analysis of pharmaceuticals.           


analgine; 18-molybdo-2-phosphate; sequential injection analysis

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