PECULIARITIES OF THE MOLECULAR WEIGHT DISTRIBUTION OF FLUORESCEIN-CONTAINING COPOLYESTERS SYNTHESIZED BY THE STEGLICH REACTION

Authors

  • Mariia V. Yakoviv Lviv Polytechnic National University, Ukraine https://orcid.org/0000-0001-9406-5187
  • Sergiy М. Varvarenko Lviv Polytechnic National University, 12, Stepan Bandera str., Lviv, 79013, Ukraine,
  • Volodymyr Ya. Samaryk Lviv Polytechnic National University, 12, Stepan Bandera str., Lviv, 79013, Ukraine, Ukraine
  • Nataliya G. Nosovа Lviv Polytechnic National University, 12, Stepan Bandera str., Lviv, 79013, Ukraine, Ukraine
  • Nataliia V. Fihurka Lviv Polytechnic National University, 12, Stepan Bandera str., Lviv, 79013, Ukraine, Ukraine
  • Olha V. Maikovych Lviv Polytechnic National University, 12, Stepan Bandera str., Lviv, 79013, Ukraine,
  • Iryna A. Dron Lviv Polytechnic National University, 12, Stepan Bandera str., Lviv, 79013, Ukraine,
  • Stanislav A. Voronov Lviv Polytechnic National University, 12, Stepan Bandera str., Lviv, 79013, Ukraine,

DOI:

https://doi.org/10.15421/082002

Keywords:

molecular mass distribution, copolyesters, fluorescein, Steglich reaction, drug delivery systems.

Abstract

The properties of polymers are substantially determined by their molecular mass and molecular mass distribution. At the same time, the average molecular mass of the polymers does not characterize them complete enough, particularly it does not describe the properties of the polymers of special purpose, which are produced for drug delivery and drug release. In this case the accurate assessment of the properties of polymers is especially needed. The article deals with the research of the composition of fractions and functional homogeneity of new amphiphilic copolyesters. Fluorescein-containing amphiphilic copolyesters of N-acyl derivatives of glutamic acid and polyether diols, which form self-stabilized dispersions in aqueous media can be considered as promising multifunctional polymers and may be used in biomedicine.

The molecular mass fractionation of copolyesters was carried out with the use of dialysis. The obtained polymers and their fractions were analyzed by exclusion chromatography and functional analysis, the surface tension was determined.

A detailed molecular mass distribution of copolyesters was obtained byusing the efficient exclusion chromatography, as well as due to the rather high mass of the monomers. The content of individual fractions, their functionality and colloid-chemical properties were quantitatively compared. It was shown that despite the different molecular mass the individual fractions of a copolyester were homogeneous with identical properties. This allowed us to describe  such copolyesters as the good base  for the creation of drug delivery systems and nanodiagnostics.

Author Biography

Mariia V. Yakoviv, Lviv Polytechnic National University

науковий співробітник, кафедра органічної хімії Інституту хімії та хімічних технологій

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Published

2020-05-04

Issue

Vol. 28 No. 1 (2020): Journal of Chemistry and Technologies

Section

Organic Chemistry

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