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Effect of plasticizer on the characteristics of molecularly imprinted polymer based potentiometric sensor for propranolol

Olga V. Gurtova, Lei Ye, Fedor A. Chmilenko


The effect of different plasticizers on the performance and selectivity coefficient of molecularly imprinted polymer (MIP) based potentiometric sensor in mixed non-aqueous mediums was first investigated. The research was undertaken for propanolol imprinted MIP. Plasticizers (di-n-octyl phthalate (DOP), dibutyl phthalate (DBP) and dioctyl sebacate (DOS)) were used in MIP based sensors for potentiometric determination of propranolol, as well as to change the resistance of the sensing polyvinylchloride membrane and to improve the detection limit and selectivity of the electrodes. For propranolol-selective sensors, the nature of plasticizer influences distribution of MIP particles in polyvinylchloride, slope of electrode function, linear range and selectivity coefficients. The applicability of the proposed sensors was tested by potentiometric propranolol determination in aqueous modeling solution with the use of tablets of pharmaceutical formulation.        


plasticizer; molecular imprinted polymer; propranolol; potentiometric sensor; MIP-based sensor; MIP microspheres

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