Effect of plasticizer on the characteristics of molecularly imprinted polymer based potentiometric sensor for propranolol

Authors

  • Olga V. Gurtova Oles Honchar Dnipropetrovsk National University, Ukraine https://orcid.org/0000-0002-7289-8484
  • Lei Ye Chemical Center, Lund University, Sweden
  • Fedor A. Chmilenko Oles Honchar Dnipropetrovsk National University, Ukraine

DOI:

https://doi.org/10.15421/081302

Keywords:

plasticizer, molecular imprinted polymer, propranolol, potentiometric sensor, MIP-based sensor, MIP microspheres

Abstract

The effect of different plasticizers on the performance and selectivity coefficient of molecularly imprinted polymer (MIP) based potentiometric sensor in mixed non-aqueous mediums was first investigated. The research was undertaken for propanolol imprinted MIP. Plasticizers (di-n-octyl phthalate (DOP), dibutyl phthalate (DBP) and dioctyl sebacate (DOS)) were used in MIP based sensors for potentiometric determination of propranolol, as well as to change the resistance of the sensing polyvinylchloride membrane and to improve the detection limit and selectivity of the electrodes. For propranolol-selective sensors, the nature of plasticizer influences distribution of MIP particles in polyvinylchloride, slope of electrode function, linear range and selectivity coefficients. The applicability of the proposed sensors was tested by potentiometric propranolol determination in aqueous modeling solution with the use of tablets of pharmaceutical formulation.        

Author Biographies

Olga V. Gurtova, Oles Honchar Dnipropetrovsk National University

        

Lei Ye, Chemical Center, Lund University

        

Fedor A. Chmilenko, Oles Honchar Dnipropetrovsk National University

        

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Published

2014-02-27

Issue

Vol. 21 No. 19 (2013): Bulletin of Dnipropetrovsk University. Series Chemistry

Section

Analytical Chemistry

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Copyright (c) 2014 Vìsnik Dnìpropetrovsʹkogo unìversitetu. Serìâ Hìmìâ

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