Synthesis and alkylation of amide obtained by N-Phthaloylglycine and himic acid hydrazide

Authors

  • Danil D. Ozerniy Oles Honchar Dnipropetrovsk National University, 72 Gagarin Ave., Dnipropetrovsk 49010, Ukraine
  • Inna V. Kurinna Oles Honchar Dnipropetrovsk National University, 72 Gagarin Ave., Dnipropetrovsk 49010, Ukraine
  • Yaroslav S. Bondarenko Oles Honchar Dnipropetrovsk National University, 72 Gagarin Ave., Dnipropetrovsk 49010, Ukraine https://orcid.org/0000-0002-8291-4863

DOI:

https://doi.org/10.15421/081512

Keywords:

hydrazide, himic acid, N-phthaloylglycine

Abstract

Himic acid hydrazide derivatives are promising in terms of practical use compounds due to their wide range of biological effects (primarily neurotropic activity) and their synthetic potential. Earlier investigated in detail the methods of synthesis of hydrazones, urea, amide and imide derivatives of himic acid hydrazide. Also known diverse biological action of N-Phthaloylglycine, which could serve as an effective protection for the amino group of glycine and has interesting structural features that contribute to the formation of supramolecular complexes. The methodology of synthesis of 2-(Phthalimidoyl)-N-benzyl-N-(4-azatricyclo[5.2.1.02-endo,6-endo]dec-8-ene-3,5-dione-4-yl)acetamide, including obtaining of 2-(Phthalimidoyl)-N-(4-azatricyclo[5.2.1.02-endo,6-endo]dec-8-ene-3,5-dione-4-yl)acetamide based on himic acid hydrazide acid and Phthalylglycyl chloride and alkylation of obtained product. Found that acceptable yield is observed during the alkylation reaction in boiling solution of anhydrous acetone in the presence of excess calcined potassium carbonate. The structure of obtained products was confirmed by analyzing the 1H NMR spectrum.

Author Biographies

Inna V. Kurinna, Oles Honchar Dnipropetrovsk National University, 72 Gagarin Ave., Dnipropetrovsk 49010

Undergraduate student, Department of Organic Chemistry, Bachelor of Chemistry

Yaroslav S. Bondarenko, Oles Honchar Dnipropetrovsk National University, 72 Gagarin Ave., Dnipropetrovsk 49010

Associate Professor of Organic Chemistry Department, PhD in Organic Chemistry

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Published

2016-03-17

Issue

Vol. 23 No. 2 (2015): Bulletin of Dnipropetrovsk University. Series Chemistry

Section

Organic Chemistry

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Copyright (c) 2015 Oles Honchar Dnipropetrovsk National University

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