The complexes structures of chromium(III) with ethylglycine and alanine

Line A. Chernushenko


The reaction of chromium(III) chloride with the amino acid ethylglycine in a 1:1 molar ratio of metal to ligand has been performed. The complex with monodentate coordinated ethylglycine [Cr(CH3СН2CH(NH3)COO)(H2O)3Cl2]Cl∙3H2O (І) has been synthesized. Interaction of compound (І) with the α-аlanine results in formation of different-ligand complex [Cr(CH3СН2CH(NH3)COO)(СН3CH(NH3)COO)(H2O)3Cl]Cl2 (ІІ). The complexes I and II have been analyzed by IR and UV/Vis spectroscopy. Significant difference in wave numbers of carboxylic group valence vibritations (nas(COO)–νs(COO)=220 cm–1 for (I) and nas(COO)–ν s(COO)=244 cm–1 for (II))confirms that both amino aсids are coordinated to Cr3+ by oxygen of carboxyl group. Compounds (І–ІІ) have the octahedral structure. Two bands of transition (4Т1g¬4A2g and4Т2g¬4A2g) have been observed in the visible part of the spectrum and one band of transition (4Т1g(Р¬4A2g in UV region. The parameters of crystal field of complexes have been calculated (Dq = 1640 cm–1, В= 627 cm–1 and b = 0.61 for (I) and Dq = 1700 cm–1 В= 553 cm–1 and b = 0.54 for (IІ)). The computer three-dimension models of complexes (II) has been created. Geometrical parameters of complexes have been calculated at HF/6-31G(D) level of theory.


Сhromium; complex connections; amino acids; аlanine; ethylglycine


Vincent, J. B. (2010). Chromium: celebrating 50 years as an essential element?. Dalton Trans., 39(16), 3787–3794. doi:10.1039/b920480f CrossRef

Mertz, W. (1993). Chromium in human nutrition: a review. J. Nutr., 123(4), 626–633.

Cooper, J. A., Blackwell, L. F., & Buckley, P. D. (1984). Chromium(III) complexes and their relationship to the glucose tolerance factor. Part II. Structure and biological activity of amino acid complexes. Inorg. Chim. Acta., 92(1), 23–31. doi:10.1016/S0020-1693(00)80060-2 CrossRef

Kegley, E. B., Spears, J. W., & Eisemann, J. H. (1997). Performance and glucose metabolism in calves fed a chromium-nicotinic acid complex or chromium chloride. J. Dairy Sci., 80(8), 1744–1750. doi:10.3168/jds.S0022-0302(97)76107-1 CrossRef

Vaidyanathan, V. G., Asthana, Ya., & Nair, B. U. (2013). Importance of ligand structure in DNA/protein binding, mutagenicity, excision repair and nutritional aspects of chromium(III) complexe. Dalton Trans. 42, 2337-2346. doi:10.1039/c2dt32124f CrossRef

Mowat, D. N., Chang, X., & Yang, W. Z. (1993). Chelated chromium for stressed feeder calves. Can. J. Anim. Sci., 73(1), 49–55. doi:10.4141/cjas93-004 CrossRef

Hayirli, A., Bremmer, D. R., Bertics, S. J., Socha, M. T., & Grummer, R. R. (2001). Effect of chromium supplementation on production and metabolic parameters in periparturient dairy cows. J. Dairy Sci., 84(5), 1218–1230. doi:10.3168/jds.S0022-0302(01)74583-3 CrossRef

Zhitkovich, A., Voitkun, V., & Costa, M. (1995). Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate. Carcinogenesis, 16(4), 907-913. doi:10.1093/carcin/16.4.907 CrossRef

Staniek, H., Krejpcio, Z., Iwanik, K., Szymusiak, H., & Wieczorek, D. (2011). Evaluation of the acute oral toxicity class of trinuclear chromium(III) glycinate complex in rat. Biol. Trace Elem. Res., 143(3), 1564-1575. doi:10.1007/s12011-011-8959-3 CrossRef

Maciejewska, G., Cieślak-Golonka, M., Staszak, Z., & Szeląg, A. (2002). Homo-and hetero-nuclear chromium(III) complexes with natural ligands. Part 1. Spectroscopic and mass spectra studies on ternary [M–L1–L2] systems]. Transition Met. Chem., 27(5), 473-480. doi:10.1023/A:1015604410186 CrossRef

Chernushenko, L. A., & Kislicina, A. B. (2013). [The structures of comlexes chromium(III) with cystine and rthylglycine]. Visnik Dnipropetrovsʹkogo universitetu Seria Himia, 21(20 (3/1)), 49-54 (in Russian). doi:10.15421/081318 CrossRef

Chernushenko, L. A., & Bezugla, A. (2012). [Electronic spectra of complexes of chromium(III)]. Bulletin of Dnipropetrovsk University Series Chemistry, 20(18), 124-126 (in Russian). Retrieved from

Chernushenko, L. A., Vinichenko, I. G., & Zegzhda, G. D. (1998). [Complexes of chromium (III) with monodentate coordinated cysteine]. Ukr. Chem. J. 64(6), 77-81 (in Russian).

Marai, H., Kita E., Kiersikowska, E., Kuchta, S., Bajek, A., & Drewa, T. (2012). Kinetic studies on H+-catalysed aquation of chromium(III)-oxalato-asparaginato and chromium(III)-oxalato-histidinato complexes. Transition Met. Chem. 37(2), 337-344. doi:10.1007/s11243-012-9594-3 CrossRef

Drago, R. (1967). [Physical methods in inorganic chemistry], Moskow, Russian Federation: Mir.

Nakamoto, K. (1991). [Infrared and Raman Spectra of Inorganic and Coordination Compounds]. Moskow, Russian Federation: Mir.

Velichko, L. V., Golenko A. A., & Shtemenko A. V. (2012). [Complexes of dirhenium(III) with 3-amino-1-adamantantcarboxylic acid]. Ukr. Chem. J., 78(3), 20-24 (in Russian).

Sharma, R. K., Tiwari, B., & Tomar, J. S. (2013) Synthesis and characterization of CNTs using egg albumin & Metal (Cr+3). Int. J. Adv. Res. Sci. Technol. 2(1), 27-29. Retrieved from

Budiasih, K. S., Anwar, C., Santosa, S. J., & Ismail, H. (2015). Development of the Synthesis of Chromium and Molybdenum – Amino acid Complexes: A Green Chemistry Approach. Adv. Mater. Res. 1101, 276–279. doi:10.4028/ CrossRef

Arstamyan, J. M., & Mkrtchyan, K. (2006). [Extraction-definition absorptiometric acridine yellow chromium in natural and waste waters]. Chem. J. Armenia, 59(3), 39–43 (in Russian).



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