Main directions of development in 1,4-dihydropyridines chemistry – a review

Authors

  • Olena Yu. Nesterova Oles Honchar Dnipropetrovsk National University, Ukraine
  • H. O. Hryshchenko Oles Honchar Dnipropetrovsk National University, Ukraine

DOI:

https://doi.org/10.15421/081308

Keywords:

1, 4-dihydropyridines, biological activity, pharmaceutical drugs, synthesis, aromatization, oxidation

Abstract

This review covers the literature published over the last 5 years on the practical use, synthesis, and oxidation of 1,4-dihydropyridines (1,4-DHP). A summary is given on recent research on the biological activity of 1,4-DHP (Hantzsch esters) as antioxidants and calcium channel antagonists. The article provides information about the main trends in the development of pharmaceuticals based on 1,4-DHP. The main directions of the synthesis of 1,4-DHP systems, closely linked to the development of new biologically active substances, are discussed. New and traditional methods for the aromatization of 1,4-DHP are summarized, including recent studies on the mechanism of this reaction.

  

Author Biographies

Olena Yu. Nesterova, Oles Honchar Dnipropetrovsk National University

  

H. O. Hryshchenko, Oles Honchar Dnipropetrovsk National University

  

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Published

2014-03-01