Sequential injection spectrophotometric determination of analgine in pharmaceutical formulations using 18-molybdo-2-phosphate heteropoly anion as chromogenic reagent

Authors

  • Mohammed Khair E. A. Al-Shwaiyat Zarka University college, Al-Balqa’ Apllied University, Jordan
  • Andriy B. Vishnikin Oles Honchar Dnipropetrovsk National University, Ukraine
  • Ludmila P. Tsiganok Oles Honchar Dnipropetrovsk National University, Ukraine
  • Ekaterina V. Kabashnaya Oles Honchar Dnipropetrovsk National University, Ukraine
  • Svetlana A. Khmelovskaya Oles Honchar Dnipropetrovsk National University, Ukraine
  • Vasil Andruch P.J. Šafarik University, Slovakia
  • Yaroslav R. Bazel P.J. Šafarik University, Slovakia
  • Hana Sklenářová Charles University, Czechia
  • Petr Solich Charles University, Czechia

DOI:

https://doi.org/10.15421/081301

Keywords:

analgine, 18-molybdo-2-phosphate, sequential injection analysis

Abstract

Simple, sensitive and selective sequential injection analysis (SIA) method for the analgine determination has been developed on the basis of fast reaction between analgine and 18-molybdo-2-phosphate heteropoly anion (18-MPA). Under found optimal conditions (0.01 M HCl, C(18-MPA) = 2 mmol/L) linear calibration curve was obtained over the range from 0.5 to 80 mg/L of analgine, and detection limit (S/N = 3) was 0.2 mg/L. The proposed SIA method has high sample throughput of 45 h-1 and small reagent consumption (0.08 mL). The procedure was successfully applied to the analysis of pharmaceuticals.           

Author Biographies

Mohammed Khair E. A. Al-Shwaiyat, Zarka University college, Al-Balqa’ Apllied University

           

Andriy B. Vishnikin, Oles Honchar Dnipropetrovsk National University

           

Ludmila P. Tsiganok, Oles Honchar Dnipropetrovsk National University

           

Ekaterina V. Kabashnaya, Oles Honchar Dnipropetrovsk National University

           

Svetlana A. Khmelovskaya, Oles Honchar Dnipropetrovsk National University

           

Vasil Andruch, P.J. Šafarik University

           

Yaroslav R. Bazel, P.J. Šafarik University

           

Hana Sklenářová, Charles University

           

Petr Solich, Charles University

           

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Published

2014-03-12