METHODS OF SYNTHESIS OF HYDROXYANTHRAQUINONE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

Authors

  • Vasyl I. Shupeniuk Vasyl Stefanyk Precarpathian National University
  • Tetyana N. Taras Precarpathian National University. V. Stefanyk
  • Oksana P. Sabadakh Precarpathian National University. V. Stefanyk
  • Evgeny R. Luchkevich Precarpathian National University. V. Stefanyk
  • Nikolay P. Matkivsky Precarpathian National University. V. Stefanyk

DOI:

https://doi.org/10.15421/jchemtech.v29i2.225941

Keywords:

1(2)-гідроксиантрахінон; фталевий ангідрид; реакція Дільса-Альдера; реакція Фріделя-Крафтса; діазотування; протипухлинна активність; токсичність

Abstract

Hydroxyanthraquinones are active components of many traditional medicinal plants, including Cassia acutifolia, Rhamnus frangula, Rheum rhabarbarum, Aloe vera. For the first time, the methods of obtaining synthetic derivatives of hydroxyanthraquinone are generalized and the spectrum of their biological activity and toxic effect on the human body is described. Some hydroxyanthraquinone derivatives have shown potential in the treatment of acute pathological conditions. The review is devoted to the synthesis of hydroxyanthraquinone derivatives obtained by reactions of Friedel-Crafts, Diels-Alder, nucleophilic substitution, diazotization, cycloaddition according to the publications of the SciFinder and Reaxys databases for the last 20 years. The first methods of industrial production of hydroxyanthraquinone were the catalytic oxidation of anthracene obtained from coal tar. Derivatives of phthalic anhydride and phenol were most often used as starting materials for obtaining hydroxy groups in the anthraquinone ring. Hydroxy derivatives of the anthraquinone series were obtained as by-products in the reactions of Zandmeyer, Ullmann, Meyerwein and others described in the review.

Author Biographies

Vasyl I. Shupeniuk, Vasyl Stefanyk Precarpathian National University

інженер кафедри хімії середовища та хімічної освіти

Tetyana N. Taras, Precarpathian National University. V. Stefanyk

завідуюча кафедрою 

кандидат хімічних наук, доцент 

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Published

2021-07-20