PREPARATION AND RESEARCH OF PROPERTIES OF COMBINED ALGINATE/GELATIN HYDROGELS

Authors

  • Marta M. Bukartyk Lviv Polytechnic National University, Ukraine
  • Nataliia G. Nosova Lviv Polytechnic National University, Ukraine
  • Olha V. Maikovych Lviv Polytechnic National University, Ukraine
  • Nataliia M. Bukartyk Lviv Polytechnic National University, Ukraine
  • Anna V. Stasiuk Lviv Polytechnic National University, Ukraine
  • Iryna A. Dron Lviv Polytechnic National University, Ukraine
  • Nataliia V. Fihurka Lviv Polytechnic National University, Ukraine
  • Semen V. Khomyak Lviv Polytechnic National University, Ukraine
  • Dmytro D. Ostapiv Institute of Animal Biology NAAS, Ukraine
  • Vasyl V. Vlizlo Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Ukraine
  • Volodymyr Ya. Samaryk Lviv Polytechnic National University, Ukraine
  • Serhii M. Varvarenko Lviv Polytechnic National University, Ukraine

DOI:

https://doi.org/10.15421/jchemtech.v30i1.242230

Keywords:

hydrogel, sodium alginate, gelatin, polymerization, wound healing, calcium

Abstract

The work presents the studies on the synthesis of hydrogel material based on the natural biopolymers (sodium alginate and gelatin) for medical applications. Sodium alginate and gelatin are biocompatible, non-toxic, biodegradable polymers and renewable raw materials. Combined alginate gelatin hydrogels are formed due to the formation of a hydrogel network by simultaneous cross-linking of calcium ions of sodium alginate macromolecules, gelatin, and macro-chains of rarely cross-linked polyacrylic acid. The optimal synthesis conditions (reagent concentrations, the molar ratio of calcium ions to the number of carboxyl groups Ca2+/COOH-) of the combined hydrogels with satisfactory physicochemical and mechanical properties are determined. The dependences of the mechanical properties of alginate-gelatin hydrogels on the degree of swelling indicate a wide range of their satisfactory performance characteristics. The studies on sorption and release of analgesics (lidocaine and novocaine) show long-term release of drugs and allow predicting the possibility of their prolonged delivery. In vitro cytotoxicity analysis proved the absence of toxic effect on living cells. The results suggest that the obtained combined alginate-gelatin hydrogels are a promising material for producing hydrogel dressings for wound care.

Author Biographies

Nataliia G. Nosova, Lviv Polytechnic National University

D.Sc. in Engineering, Senior Research Officer

Nataliia M. Bukartyk, Lviv Polytechnic National University

Research Officer

Dmytro D. Ostapiv, Institute of Animal Biology NAAS

D.Sc. in Agricultural, Senior Research Officer, Head of the laboratory

Vasyl V. Vlizlo, Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies

D.Sc. in Veterinary, Full Professor, Academician

Volodymyr Ya. Samaryk, Lviv Polytechnic National University

D.Sc. in Chemistry, Full Professor, Leading Researcher

Serhii M. Varvarenko, Lviv Polytechnic National University

D.Sc. in Chemistry, Full Professor, Leading Researcher

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Published

2022-04-27

Issue

Vol. 30 No. 1 (2022): Journal of Chemistry and Technologies

Section

Organic Chemistry

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