A GREEN SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF DROTAVERINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS USING FORMATION OF ION ASSOCIATION COMPLEX WITH ERYTHROSINE
DOI:
https://doi.org/10.15421/jchemtech.v29i3.242348Keywords:
Drotaverine hydrochloride, Erythrosine, Spectrophotometry, Ion association complex, Pharmaceutical preparationsAbstract
For the determination of drotaverine hydrochloride (DRH), a new, simple and environmentally friendly non-extractive spectrophotometric method was developed, based on a direct reaction with the fluorescein dye erythrosine (ER). The color change occurs due to the formation of an ion-association complex (IA) of the protonated form of the analyte with the monoanionic form of ER. It is not necessary to use a surfactant to solubilize the IA precipitate or extract it with toxic organic solvents. A new bathochromically shifted band appears in the absorption spectrum at 560 nm. Its origin is attributed to the aggregation of dye anions. The formation of poorly soluble IA promotes the aggregation of dye anions. IA is completely formed at pH 4.4 in an acetate buffer medium after 3-5 min. The absorption remains constant for two hours. Under optimal reaction conditions, the calibration curve was linear in the range from 0.4 to 3 μmol L-1 with a detection limit of 0.10 μmol L-1 (40 μg L-1) and a correlation coefficient of 0.9996. The molar absorptivity of IA is 3.8×104 mol-1 L cm-1. The stoichiometry of the complexes formed between DRH and ER, determined by Job's continuous variation method, was 1 : 1. A new simple method for calculating equilibrium constants based on visual inspection and coincidence of experimental and calculated curves describing the dependence of the mole fraction of IA and other particles on the pH of the solution was proposed. The calculated formation constant IA 2×106 indicates its high stability. The developed method has been successfully applied to determine DRH in pharmaceuticals.
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