• Viktoriia V. Konovalova National University “Kyiv-Mohyla Academy”, Ukraine
  • Iryna S. Kolesnyk National University of Kyiv-Mohyla Academy , Ukraine
  • Ganna A. Pobigay National University of Kyiv-Mohyla Academy, Ukraine
  • Andriy I. Marynin National University of Food Technologies, Ukraine




microcapsules; membrane emulsification; interpolymeric complex; chitosan; carboxymethyl cellulose; drug delivery; papaverine hydrochloride.


In this work, thermo- and pH-sensitive microcapsules were obtained based on the polyelectrolyte complex of chitosan-carboxymethyl cellulose by the membrane emulsification. Microcapsules with a size of 200-250 nm were produced using a track PET membrane with a pore size of 0.1 μm. The stability of microcapsules, their size distribution, zeta potential of the surface, and the effect of temperature and pH on particle size were studied by the dynamic light scattering. The formation of the complex was confirmed by IR spectroscopy, and the structure of the complexes at different ratios of polymers was analyzed by viscosimetry. The kinetics of papaverine hydrochloride release from microcapsules based on chitosan:CMC complexes at a ratio of 1:1 and 3:2 was studied. This method is a simple technique for obtaining microcapsules from interpolymer complexes by alternately introduction of polymer solutions into the dispersion medium, which allows to obtain monodisperse suspensions of a certain size and effective immobilization of a wide range of pharmaceutical ingredients.

Author Biography

Viktoriia V. Konovalova, National University “Kyiv-Mohyla Academy”

Associate professor, Department of Chemistry


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