MICROCAPSULES BASED ON CHITOSAN-CARBOXYMETHYL CELLULOSE COMPLEXES OBTAINED BY MEMBRANE EMULSIFICATION
DOI:
https://doi.org/10.15421/jchemtech.v30i1.252354Keywords:
microcapsules; membrane emulsification; interpolymeric complex; chitosan; carboxymethyl cellulose; drug delivery; papaverine hydrochloride.Abstract
In this work, thermo- and pH-sensitive microcapsules were obtained based on the polyelectrolyte complex of chitosan-carboxymethyl cellulose by the membrane emulsification. Microcapsules with a size of 200-250 nm were produced using a track PET membrane with a pore size of 0.1 μm. The stability of microcapsules, their size distribution, zeta potential of the surface, and the effect of temperature and pH on particle size were studied by the dynamic light scattering. The formation of the complex was confirmed by IR spectroscopy, and the structure of the complexes at different ratios of polymers was analyzed by viscosimetry. The kinetics of papaverine hydrochloride release from microcapsules based on chitosan:CMC complexes at a ratio of 1:1 and 3:2 was studied. This method is a simple technique for obtaining microcapsules from interpolymer complexes by alternately introduction of polymer solutions into the dispersion medium, which allows to obtain monodisperse suspensions of a certain size and effective immobilization of a wide range of pharmaceutical ingredients.
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