MICROEMULSION „WATER IN OIL“ AS A POTENTIAL SYSTEM FOR ASCORBIC ACID ENCAPSULATION
DOI:
https://doi.org/10.15421/jchemtech.v30i2.254368Keywords:
Microemulsion”, “micellization”, “phase diagram”, “surfactant”, “cosurfactant”, “dynamic light scattering “, “refractive indeks”, „electrical conductivity”, „surface tension “.Abstract
Microemulsions are optically isotropic and thermodynamically stable systems of water, oil and surfactant, often in combination with a cosurfactant which is required for optimal formation of microemulsion with a smaller aggregate radius and greater curvature of the interfacial layer. The full potential of microemulsion systems has yet to be realized and a lot of innovation in the field of microemulsion technology is expected. They have numerous advantages due to spontaneous formation, ease of manufacturing and scale-up, thermodynamic stability, ability to improve drug solubilization, and bioavailability. This work describes microemulsion systems which contain nonionic surfactants Tween 80 and Span 80, isopropyl myristate as the oil phase and purified water. From the most suitable microemulsion region, samples were selected and analyzed, blank and with encapsulated ascorbic acid, by measuring the size distribution of microemulsion aggregates, refractive index, electrical conductivity, and surface tension.
References
Wang, X., Zan, M., Amuti, A., Shu, Q., Wang, Z. (2021). Evaluation of the oxidation stability and anti-cancer cell activity of Paeonia ostii seed oil and its linolenic acid fractions delivered as microemulsions, J. Mol. Liq., 342, 117579.
https://doi.org/10.1016/j.molliq.2021.117579
S. Sargazia, Hajinezhadb M. R., Baranici, M., Rahdard, A., Shahrakia, Sh., Karimie, P., Cucchiarinif, M., Khatamig, M., Pandey, S. (2021). Synthesis, characterization, toxicity and morphology assessments of newly prepared microemulsion systems for delivery of valproic acid, J. Mol. Liq., 338, 116625
https://doi.org/10.1016/j.molliq.2021.116625
Amuti, A., Wang, X., Zan, M., Lv, S., Wang, Z. (2021). Formulation and characterization of curcumin-loaded microemulsions: Evaluation of antioxidant stability and in vitro release, J. Mol. Liq., 336, 116881.
1016/j.molliq.2021.116881.
Špaglová M., Čuchorová M., Šimunková V., Matúšová D., Čierna M., Starýchová L., Bauerová K. (2020). Possibilities of the microemulsion use as indomethacin solubilizer and its effect on in vitro and ex vivo drug permeation from dermal gels in comparison with transcutol®, Drug Dev. Ind. Pharm., 46(9), 1468–1476. 10.1080/03639045.2020.1802483.
Mitsou, E., Pletsa, V., Sotiroudis, G. T., Panine, P., Zoumpanioti, M., Xenakis, A. (2020). Development of a microemulsion for encapsulation and delivery of gallic acid. The role of chitosan,” Colloids Surfaces B Biointerfaces, 190(March), 110974. 10.1016/j.colsurfb.2020.110974.
Benigni, M. Pescina, S. Grimaudo, M. A. Padula, C. Santi, P. Nicoli, S. (2018). Development of microemulsions of suitable viscosity for cyclosporine skin delivery, Int. J. Pharm., 545(1–2), 197–205.
1016/j.ijpharm.2018.04.049.
Tabosa, M. A. M., de Andrade, A. R. B., Lira, A. A. M., Sarmento, V. H. V., de Santana, D. P. L., Leal, (2017). Microemulsion Formulations for the Transdermal Delivery of Lapachol, AAPS Pharm Sci Tech, 19(4), 1837–1846, 2018. 10.1208/s12249-018-0995-2.
Froelich, A., Osmałek, T., Snela, A., Kunstman, P., Jadach, B., Olejniczak, M., Roszak, G., Białas, W. (2017). Novel microemulsion-based gels for topical delivery of indomethacin: Formulation, physicochemical properties and in vitro drug release studies, J. Colloid Interface Sci., 507, 323–336. 10.1016/j.jcis.2017.08.011.
Kaur G., Mehta, S. K. (2017). Developments of Polysorbate (Tween) based microemulsions: Preclinical drug delivery, toxicity and antimicrobial applications,” Int. J. Pharm., 529(1–2), 134–160. 10.1016/j.ijpharm.2017.06.059.
J. Fuchs, “Potentials and limitations of the natural antioxidants RRR-alpha- tocopherol, L-ascorbic acid and β-carotene in cutaneous photoprotection,” Free Radic. Biol. Med., vol. 25, no. 7, pp. 848–873, 1998, doi: 10.1016/S0891-5849(98)00161-0.
Su, R. Fan, W., Yu, Q., Dong, X., Qi, J., Zhu, Q., Zhao, W., Wu, W., Chen, Zh., Li Y., Lu, Y. (2017). Size-dependent penetration of nanoemulsions into epidermis and hair follicles: Implications for transdermal delivery and immunization, Oncotarget, 8(24), 38214–38226. 10.18632/oncotarget.17130.
Nastiti, C. M. R. R., Ponto, T., Abd, E., Grice, J. E., Benson, H. A. E., Roberts, M. S. (2017). Topical nano and microemulsions for skin delivery, Pharmaceutics, 9(4), 1–25. 10.3390/pharmaceutics9040037.
Padayatty, S. J., Katz, A., Wang, Ya., Eck, P., Kwon, O., Lee, Je-H., Chen, Sh., Corpe, Ch., Dutta, A., Dutta S. K., Levine M. (2003). Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention, J. Am. Coll. Nutr., 22(1), 18–35.
1080/07315724.2003.10719272.
Ae-Ri Cho Lee, K. T. (1998). Characterization of Skin Permeation of Vitamin C : Theoretical Analysis of Penetration Profiles and Differential Scanning Calorimetry Study, Chem. Pharm. Bull., 46, 174–177. 10.1248/cpb.46.174.
Yi, N., Chiang, Z. (2017). Topical Vitamin C and the Skin, Jcad J. Clin. Aesthetic Dermatology, 14(7), 14–17.
Gallarate, M., Carlotti, M. E., Trotta, M., Bovo, S. (1999). On the stability of ascorbic acid in emulsified systems for topical and cosmetic use, Int. J. Pharm., 188(2), 233–241, 10.1016/S0378-5173(99)00228-8.
Liu, J., Zhang, X., Zhang, H. (2014). Water /AOT/IPM/alcohol reverse microemulsions: Influence of salts and nonionic surfactants on structure and percolation behavior, J. Chem. Thermodyn., 72, 1–8, 10.1016/j.jct.2013.12.026.
Mishra, B.K., Kuanar, M., Chauhan, G. (2000). Behaviour of non-ionic microemulsion containing Tween-80, iso-amyl alcohol, hexane and water, 7(Novemb.
Eicke, H. F. Borkovec, M. Das-Gupta, B. (1989). Conductivity of water-in-oil microemulsions: A quantitative charge fluctuation model, J. Phys. Chem., 93(1), 314–317. 10.1021/j100338a062.
Liović, N., Bošković, P., Drvenica, I., Jambrak, A. R., Dropulić, A. M., Krešić, G., Nedović, V., Bugarski, B., Zorić, Z., Pedisić, S., Bilušić T. (2019). Phenolic Extracts from Vaccinium corymbosum L. Loaded in microemulsions and liposomes as enhancers of olive oil oxidative stability, Polish J. Food Nutr. Sci., 69(1), 23–33. 10.31883/pjfns-2019-0003.
Rozman B., Gašperlin, M. (2007). Stability of vitamins C and E in topical microemulsions for combined antioxidant therapy, Drug Deliv., 14(4), 235–245. 10.1080/10717540601067786.
Liu, W., Sun, D., Li, C., Liu, Q., Xu, J. (2006).Formation and stability of paraffin oil-in-water nano-emulsions prepared by the emulsion inversion point method, J. Colloid Interface Sci., 303(2), 557–563. 10.1016/j.jcis.2006.07.055.
Hsu, J. P., Nacu, A. (2003). Behavior of soybean oil-in-water emulsion stabilized by nonionic surfactant, J. Colloid Interface Sci., 259(2), 374–381. 10.1016/S0021-9797(02)00207-2.
Yew, H. C., Bin Misran, M. (2016). Nonionic Mixed Surfactant Stabilized Water-in-Oil Microemulsions for Active Ingredient in Vitro Sustained Release. J. Surfactants Deterg., 19(1), 49–56. 10.1007/s11743-015-1753-z.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Oles Honchar Dnipro National University
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
- Authors reserve the right of attribution for the submitted manuscript, while transferring to the Journal the right to publish the article under the Creative Commons Attribution License. This license allows free distribution of the published work under the condition of proper attribution of the original authors and the initial publication source (i.e. the Journal)
- Authors have the right to enter into separate agreements for additional non-exclusive distribution of the work in the form it was published in the Journal (such as publishing the article on the institutional website or as a part of a monograph), provided the original publication in this Journal is properly referenced
- The Journal allows and encourages online publication of the manuscripts (such as on personal web pages), even when such a manuscript is still under editorial consideration, since it allows for a productive scientific discussion and better citation dynamics (see The Effect of Open Access).