N-SUBSTITUTED PYRIDINE SALTS WITH PHTHALIMIDE-N-OXYL ANION

Authors

  • Hanna О. Serhieieva Independent researcher, Ukraine
  • Mykhajlo O. Kompanets L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry NAS of Ukraine, Ukraine
  • Olena Ju. Nesterova Oles Honchar Dnipro National University, Ukraine https://orcid.org/0000-0003-0732-4000

DOI:

https://doi.org/10.15421/jchemtech.v31i3.286682

Keywords:

pyridine salt derivatives; nicotinamide; N-hydroxyphthalimide; phthalimide-N-oxyl salts; N-oxyphthalimide anion.

Abstract

Currently, various biological activities of pyridine derivatives are widely studied, the type and strength of which depends on the presence of a substituent in the molecule. The aromatic pyridine ring plays an important role in the metabolism of a living organism. It is an oxidative system, cleaving the hydride in nicotinamide adenine dinucleotide (NAD+) – a component of the dehydrogenase enzyme. Derivatives of pyridine salts are part of a variety of medicines that are used for the prevention, diagnosis and treatment of diseases of the human body as well. Therefore, we synthesized new water-soluble derivatives of N-benzylpyridinium 3-carboxamide phthalimide-N-oxyl, N-propylpyridinium 3-carboxamide phthalimide-N-oxyl and N-methylpyridinium 3-carboxamide phthalimide-N-oxyl with a pyridine ring. The reactions occurred during the interaction of the corresponding N-substituted pyridine salts of nicotinamide with various phthalimide-N-oxyl salts. Also within the framework of the work, the method of joining N-oxyphthalimide anion to N-substituted pyridine molecule was investigated, selected and developed.

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Published

2023-10-28

Issue

Vol. 31 No. 3 (2023): Journal of Chemistry and Technologies

Section

Organic Chemistry

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