SIMULATION OF THE APPLICATION OF POLYMER COMPOSITE MATERIALS WITH FUNGICIDAL ACTION FOR THE PREVENTION AND TREATMENT OF ONYCHOMYCOSIS
DOI:
https://doi.org/10.15421/jchemtech.v32i3.305932Keywords:
polymer composite material, varnish with fungicidal properties, nail onychomycosisAbstract
The object of research is the process of forming the properties of polymer composite materials with fungicidal properties in the production of medical products. In this work, the problem of effective polymer composite materials with fungicidal properties, which were specially developed to protect the nail from onychomycosis pathogens, was solved. The obtained results give grounds for asserting that the developed polymer composite materials have pronounced fungicidal properties against the causative agents of onychomycosis. Thanks to the optimal composition, the developed polymer materials have the ability to diffuse into the thickness of the nail. It was established that the membrane of bull hooves is the most similar in properties and chemical composition to the human nail and can be used as a model of the human nail in the study of the fungicidal activity of polymers, as well as the determination of the diffusion of active substances in the thickness of the nail. Pronounced diffusion of active substances into the composition of the nail is explained by the presence of urea in the formulation. Also, the effectiveness of the developed polymer materials is influenced by the fact that cation active surfactants, which were not previously used in antifungal agents, were used as active substances. It is shown that almost all the proposed variants of the polymer composite material with fungicidal action are effective against onychomycosis pathogens, except for the variants that contain polyhexamethylenebiguanide hydrochloride as an active substance. The presented results can be useful in the development of polymer composite materials with fungicidal properties for the prevention and treatment of onychomycosis. The practical application of these results is possible in the production of medical products.
References
Lipner, S. R., Scher, R. K. (2019). Onychomycosis: Treatment and prevention of recurrence. Journal of the American Academy of Dermatology, 80(4), 853–867. https://doi.org/10.1016/j.jaad.2018.05.1260
Kachan, R., Zakomoldina, A., Yatsuta, I. (2023). [Creation of a polymer composite with fungicidal properties]. Visnyk Khmelnytskoho natsionalnoho universytetu, 323(4), 149–153. (in Ukrainian). https://doi.org/10.31891/2307-5732-2023-323-4-149-153
Cordoba Díaz, D., Losa Iglesias, M. E., Becerro de Bengoa Vallejo, R., Cordoba Diaz, M. (2019). Transungual Delivery of Ciclopirox Is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an In Vitro Model. Pharmaceutics, 11(1), 29. https://doi.org/10.3390/pharmaceutics11010029
Shirwaikar, A. A., Thomas, T., Shirwaikar, A., Lobo, R., Prabhu, K. S. (2008). Treatment of onychomycosis: an update. Indian journal of pharmaceutical sciences, 70(6), 710–714. https://doi.org/10.4103/0250-474X.49088
Axler, E., Lipner, S. R. (2024). Antifungal Selection for the Treatment of Onychomycosis: Patient Considerations and Outcomes. J Infection and Drug Resistance, 17, 819–843. https://doi.org/10.2147/IDR.S431526
Monti, D., Mazzantini, D., Tampucci, S., Vecchione, A., Celandroni, F., Burgalassi, S., Ghelardi, E. (2019). Ciclopirox and Efinaconazole Transungual Permeation, Antifungal Activity, and Proficiency To Induce Resistance in Trichophyton rubrum. Antimicrobial agents and chemotherapy, 63(10), e00442-19. https://doi.org/10.1128/AAC.00442-19
Nogueiras-Nieto, L., Gómez-Amoza, J. L., Delgado-Charro, M. B., Otero-Espinar, F. J. (2011). Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof: Implications for drug delivery. Journal of controlled release, 156(3), 337–344. https://doi.org/10.1016/j.jconrel.2011.08.021
Bonetti, M., Bracchi, M., Musitelli, G., Perugini, P. (2021). Production and characterization of bovine hoof membranes as standardized in vitro model for nail studies. International journal of pharmaceutics, 600, 120409. https://doi.org/10.1016/j.ijpharm.2021.120409
Gupta, A. K., Hall, D. C., Cooper, E. A., Ghannoum, M. A. (2022). Diagnosing Onychomycosis: What’s New? J. Fungi, 8(5), 464. https://doi.org/10.3390/jof8050464
Anfilova, M. R. (2018). [Therapy of onychomycosis: problematic issues and practical guidelines]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii, 3, 117–124. (in Ukrainian). https://doi.org/10.30978/UJDVK2018-3-117
Dobler, D., Gerber, M., Schmidts, T. M., Runkel, F., Schlupp, P. (2022). Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate. Pharmaceutics, 14, 2552. https://doi.org/10.3390/pharmaceutics14122552
Vrynchanu, N. O., Burmaka, O. V., Dronova, M. L., Dudikova, D. M., Suvorova, Z. S. (2018). [Study of specific activity of antifungal drugs, methodological recommendations]. Kyiv: Ministerstvo okhorony zdorovia Ukrainy, DP «Derzhavnyi ekspertnyi tsentr MOZ Ukrainy» (in Ukrainian).
Eichenfield, L. F., Friedlander, S. F. (2017). Pediatric onychomycosis: the emerging role of topical therapy. Journal of drugs in dermatology: JDD, 16(2), 105–109.
Mayser, P., Niehaus, M. (2023). Onychomycosis guideline update. International Review Journal Evid Self Med, 3, 230001. https://doi.org/10.52778/efsm.23.0001
Lipner, S. R. (2021). Nail Disorders: Diagnosis and Management. Dermatologic Clinics, 39(2), i. https://doi.org/10.1016/S0733-8635(21)00005-X
Doloff, J. C., Domb, A. J., Kunduru, K. R., Farah, S. (2019). Introduction to Microbes and Infection in the Modern World. Antimicrobial Materials for Biomedical Applications. London, UK: Royal Society of Chemistry, 38–67. https://doi.org/10.1039/9781788012638
Rice, L. B. (2008). Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. The Journal of infectious diseases, 197(8), 1079–1081. https://doi.org/10.1086/533452
Jonas, O. B., Irwin, A., Berthe, F. C. J., Le Gall, F. G., Marquez, P. V. (2017). Drug-resistant infections : a threat to our economic future (Vol. 2): final report (English). HNP/Agriculture Global Antimicrobial Resistance Initiative Washington, D.C., USA: World Bank Group. http://documents.worldbank.org/curated/en/323311493396993758/final-report
Cheung, C. W. S., Beech, I. B. (1996). The use of biocides to control sulphate‐reducing bacteria in biofilms on mild steel surfaces. Biofouling, 9(3), 231–249. https://doi.org/10.1080/08927019609378305
Zhang, H., Liu, L., Hou, P., Liu, J., Fu, S. (2021). Design, Synthesis, Antibacterial, and Antitumor Activity of Linear Polyisocyanide Quaternary Ammonium Salts with Different Structures and Chain Lengths. Molecules, 26, 5686. https://doi.org/10.3390/molecules26185686
Padnya, P. L., Terenteva, O. S., Akhmedov, A. A., Iksanova, A. G., Shtyrlin, N. V., Nikitina, E. V., Krylova, E. S., Shtyrlin, Y. G., Stoikov, I. I. (2021). Thiacalixarene based quaternary ammonium salts as promising antibacterial agents. Bioorganic & Medicinal Chemistry, 29, 115905. https://doi.org/10.1016/j.bmc.2020.115905
Frolov, N., Detusheva, E., Fursova, N., Ostashevskaya, I., Vereshchagin, A. (2022). Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study. Pharmaceuticals, 15, 514. https://doi.org/10.3390/ph15050514
Rózga-Wijas, K., Mizerska, U., Fortuniak, W., Chojnowski, J., Hałasa, R., Werel, W. (2007). Quaternary ammonium salts (QAS) modified polysiloxane biocide supported on silica materials. Journal of Inorganic and Organometallic Polymers and Materials, 17, 605-613. https://doi.org/10.1007/s10904-007-9153-0
Heseltine, P. (2002) Disinfection, Sterilization, and Preservation, Infection Control & Hospital Epidemiology, 23(2), 109–109. https://doi.org/10.1017/S0195941700084289
Bardac 2280. Ataman Chemicals. https://atamankimya.com/sayfalaralfabe.asp?LanguageID=2&cid=3&id=2868&id2=519
Roth, B., Brill, F. H. H. (2010). Polihexanide for wound treatment–how it began. Skin pharmacology and physiology, 23(1), 4–6. https://doi.org/10.1159/000318236
Kachan, R., Strashnyi, V. (2023). [Influence of active substances on the efficiency of polymer composite materials in the form of varnish with fungicidal action]. Visnyk Khmelnytskoho natsionalnoho universytetu, 329(6), 157–160 (in Ukrainian). https://www.doi.org/10.31891/2307-5732-2023-329-6-157-160
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Oles Honchar Dnipro National University
This work is licensed under a Creative Commons Attribution 4.0 International License.
- Authors reserve the right of attribution for the submitted manuscript, while transferring to the Journal the right to publish the article under the Creative Commons Attribution License. This license allows free distribution of the published work under the condition of proper attribution of the original authors and the initial publication source (i.e. the Journal)
- Authors have the right to enter into separate agreements for additional non-exclusive distribution of the work in the form it was published in the Journal (such as publishing the article on the institutional website or as a part of a monograph), provided the original publication in this Journal is properly referenced
- The Journal allows and encourages online publication of the manuscripts (such as on personal web pages), even when such a manuscript is still under editorial consideration, since it allows for a productive scientific discussion and better citation dynamics (see The Effect of Open Access).
