SOLUBILITY STUDY OF 3-(1-(4-METHYLPHENYL)-5-PHENYLPYRROL-2-YL)PROPANOIC ACID IN ORGANIC SOLVENTS

Dmytro S. Shevchenko; Yuriy I. Horak; Viktoriia V. Matiichuk; Nadiia I. Tischenko; Mykola D.  Obushak; Iryna B.  Sobechko

doi:10.15421/jchemtech.v33i1.312615

Authors

Dmytro S. Shevchenko Lviv Polytechnic National University, Ukraine https://orcid.org/0000-0001-5119-4288
Yuriy I. Horak Ivan Franko National University of Lviv, Ukraine https://orcid.org/0000-0002-3195-2325
Viktoriia V. Matiichuk Ivan Franko National University of Lviv, Ukraine
Nadiia I. Tischenko Frantsevich Institute for Problems of Materials Science NASU, Ukraine
Mykola D. Obushak Ivan Franko National University of Lviv, Ukraine https://orcid.org/0000-0001-8146-9529
Iryna B. Sobechko Lviv Polytechnic National University, Ukraine https://orcid.org/0000-0002-0155-9944

DOI:

https://doi.org/10.15421/jchemtech.v33i1.312615

Keywords:

solubility; enthalpy of dissolution; enthalpy of fusion; enthalpy of mixing; pyrrole derivatives; N-substituted 3-(5-phenylpyrrol-2-yl)propanoic acids

Abstract

In this study solubility temperature dependence of 3-(1-(4-methylphenyl)-5-phenylpyrrol-2-yl)propanoic acid in the temperature range of 271.0–318.2 K using the gravimetric method at atmospheric pressure was experimentally determined for the first time in eight organic solvents, namely methyl acetate, ethyl acetate, acetone, acetonitrile, n-propanol, isopropanol, n-butanol, isobutanol. The primary results of experimental studies of the solubility temperature dependence for each of the studied solution systems were used to calculate the standard molar enthalpy and entropy of dissolution according to the Van't-Hoff equation. The enthalpy and entropy of fusion at the melting point were determined using the results of differential thermal analysis. The equations for the recalculation of the enthalpy and entropy of fusion to a temperature of 298.15 K are presented. Using the calculated values of enthalpy and entropy of fusion to 298.15 K, the thermodynamic parameters of the process of mixing the studied acid with organic solvents were calculated. The nature of intermolecular interactions between the solvent and the dissolved substance was analysed using thermodynamic parameters of mixing. The present study contains fundamental thermodynamic values that are of practical importance for the optimisation of processes of synthesis, processing and purification of the investigated N-substituted derivative of 3-(5-phenylpyrrol-2-yl)propanoic acid.

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