FUNGICIDAL ADDITIVE IN COSMETIC NAIL VARNISHES
DOI:
https://doi.org/10.15421/jchemtech.v33i3.321373Keywords:
cosmetic polish, biocidal additive, stability, nail onychomycosis, quaternary ammonium compounds, active pharmaceutical ingredientAbstract
The object of the study is to provide a fungicidal effect to cosmetic nail varnishes by adding a special additive to the varnishes. This work proposes an innovative approach to the use of nail varnishes with an updated chemical composition both for the aesthetic masking of defects caused by onychomycosis pathogens and for the protection of the nail plate from fungal infections. Daily use of cosmetic varnishes with a fungicidal additive allows you to protect nails from fungi. This can be used both in the treatment of nails and for the purpose of prevention in population groups with an increased risk of onychomycosis infection (elderly people, people with diabetes, people with a weakened immune system, people who often visit swimming pools, saunas, baths, etc.). The results obtained give grounds to claim that the developed additive will provide fungicidal properties to cosmetic varnishes, both colored and colorless. In addition, the fungicidal additive includes urea, which accelerates the diffusion of the active substance into the thickness of the nail. A mixture of four quaternary ammonium salts was used as the active substance. It was established that the additive has pronounced fungicidal properties against the main pathogens of onychomycosis. Therefore, it is advisable to use it to provide fungicidal properties to cosmetic varnishes. It was shown that after the introduction of the biocidal additive into the composition of cosmetic varnishes (colored and colorless), they appeared to have pronounced fungicidal activity against pathogens of mycoses. The studied cosmetic nail varnishes with the additive did not significantly change their physicochemical and organoleptic properties after its introduction both immediately and after determining stability for 16 months. The presented results may be useful in the development of a system based on cosmetic varnishes and a fungicidal additive for the prevention and treatment of onychomycosis. Practical application of these results is possible in the production of medical products.
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