ATOMIC ABSORPTION AND ATOMIC EMISSION WITH INDUCTIVELY COUPLED PLASMA DETERMINATION OF COPPER, ZINC, NICKEL IN PHARMACEUTICAL SUBSTANCES
DOI:
https://doi.org/10.15421/jchemtech.v34i1.336904Keywords:
atomic absorption and atomic emission spectrometry with inductively coupled plasma, copper, zinc, nickel, Triton X-100 solutions, ultrasonic treatment, acetylacetone, metal acetylacetonates, pharmaceutical substances, metrological characteristicsAbstract
The influence of nonionic surfactant Triton X-100 on the analytical signal in atomic absorption determination of copper, zinc, and nickel in pharmaceutical substances was investigated. The sensitivity and precision of analyte determination were increased by using Triton X-100 (w = 4 %) solutions, calibration solutions based on metal acetylacetonates, and treating the analyzed samples with ultrasound for 20 min. The sensitivity of atomic absorption determination of copper increases by 1.80 times, zinc by 1.60 times, and nickel by 1.70 times. The content of analytes in multicomponent samples was determined by atomic absorption and atomic emission spectrometry with inductively coupled plasma. The results obtained by two independent methods were compared using F- and t-criteria. It was shown that there is no significant discrepancy in these results, the difference is insignificant and is due to random statistical error. The accuracy of the analysis results was verified by varying the sample weight and using the “added-found” method. The detection limit for copper (Cmin = 0.002 μg/ml, Clit = 0.004 μg/ml), zinc (Cmin = 0.003 μg/ml, Clit = 0.004 μg/ml), and nickel (Cmin = 0.003 μg/ml, Clit =0.004 μg/ml) was calculated by atomic absorption method.
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